This chapter initiates a discussion about the mechanical aspects of TSVs. The main goal here is to provide a framework to assess the mechanical impact of the TSVs in their surroundings. First, the materials employed in TSVs and how their properties influence a via’s design is discussed. Afterward, the discussion proceeds with the mechanical impact of a via on its surroundings, especially during thermal variations. Finally, strategies for TSV placement are presented as well as methods for calculating the keep away zone.