In addition to simulating sequences of fabrication processes, the support of large-scale simulation experiments plays another important role in the TCAD domain. Simulation experiments are an indispensable aid in the development of VLSI processes and devices for studying the influence of parameter changes on the behavior of the fabricated device. Typical tasks involve about five to ten independent process parameters that are varied independently of each other, leading to up to several hundred simulation experiments for every system aspect under consideration. Due to the high costs of two-dimensional and three-dimensional simulation, the number of simulator calls - the actual invocation of an executable to numerically simulate a given fabrication process or device characteristic - submitted to a workstation or other type of computer needs to be made as small as possible, with automatically enforcing the reuse of existing results where possible. Tool control and data management necessary for such experiments in a fashion suitable for application in an industrial setting constitutes another core part of this work (cf. Chapter 6).